Nisha Sharma, PhD Portfolio Item
The level and composition of bile acids (BAs) play a crucial role in lipid and fat absorption and metabolism, which then impacts metabolic diseases such as Type 2 diabetes (T2D). BAs are amphipathic molecules synthesized from cholesterol primarily in the liver. The enzyme cytochrome P450 family 8 subfamily B member . . . Ghazaleh Eskandari-Sedighi, PhD Portfolio Item
The complex, multifaceted nature of Alzheimer’s disease (AD) challenges the detailed mechanistic understanding of this condition. It is now known that AD is over 60% hereditable and most of these heritable factors modulate brain resident immune cells, known as microglia. Accordingly, understanding the disease mechanisms, can be achieved by exploring . . . Tamas Nagy, PhD Portfolio Item
As we age, our body’s ability to regenerate itself in response to injury gets progressively worse, leading to frailty and eventually death. A major reason this happens is that specialized cells in our bodies, known as stem cells, get worse at detecting problems and kicking off the regenerative process. Determining . . . Seth Sharp, PhD Portfolio Item
Beta cells found in pancreatic islets secrete insulin in order to regulate blood glucose after a meal. Dysfunction of these cells results in an impaired ability to secrete insulin in response to glucose and is an underlying contributor to common forms of diabetes. In Type 1 diabetes lower baseline secretion . . . Jinhao (Albert) Xu, PhD Portfolio Item
Osteoarthritis (OA) is a prevalent pathological condition characterized by joint degeneration and persistent pain, affecting millions worldwide, especially older adults. Despite its widespread impact, effective treatments remain very limited. My research aims to explore the molecular and cellular changes in bone structural cells and bone-innervating nerves associated with OA, with . . . Ilia Droujinine, PhD Portfolio Item
Our organs are interconnected: they communicate to coordinate their functions. These interorgan communication networks allow our bodies to maintain a steady state, or homeostasis. This is significant as the development of many disorders, including obesity and diabetes, and their complications result from faulty communication between organs. As a result, diseases . . . Hanna Martens, PhD Portfolio Item
A broad spectrum of diseases that become more prevalent with aging – ranging from diabetes and neurodegenerative disorders to atherosclerosis, arthritis, increased cancer incidence, and heightened susceptibility to infections – can often be traced back to or exacerbated by two interconnected phenomena: inflammaging and immunosenescence. Inflammaging refers to the chronic, . . . 