Clare Hancock, PhD Portfolio Item

The over-consumption of sweet, energy-dense foods is directly linked to the development of a plethora of health complications, including obesity and type two diabetes – both of which have been on the rise in recent decades as the presence of these food types becomes more ubiquitous in our daily lives. . . .

Christopher Toomey MD, PhD Portfolio Item

Age-Related Macular Degeneration (AMD) is a leading cause of vision loss among the elderly in developed countries, affecting nearly 200 million worldwide. Unfortunately, about 80% of AMD patients with early and intermediate stages, known as “dry” AMD, currently lack effective treatment options due to a limited understanding of the disease. . . .

2024 Annual Progress Report Submission Deadline Blog Post

2024 Annual Progress Report Submission Deadline: Annual Progress Reports for all Grant Mechanisms are due on Friday, September 6, 2024 at 5:00 PM PDT. The online grant management system will...

2024 Annual Scientific Meeting Page

2024 Annual Scientific Meeting Meeting InfoPreliminary AgendaRegistration InformationRegistration FormPresentation Information Meeting Info LARRY L. HILLBLOM FOUNDATION 20th ANNUAL SCIENTIFIC SESSIONS THE MONTEREY PLAZA HOTEL & SPA MONTEREY, CA OCTOBER 21...

Yi Zeng, PhD Portfolio Item

With an aging population, neurodegenerative disorders contribute increasingly to our global health burden with no cure or effective treatments available. Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two neurodegenerative disorders that are distinct in clinical presentation but share a common underlying feature – that an essential protein named . . .

Joseph Gleeson, MD Portfolio Item

During aging, cells inadvertently acquire new mutations in the DNA of the genome that adversely impact function and can limit health. When taken collectively, these mutations produce ‘mosaicism’, because they contribute to differences in the cellular genome within a person. While mosaicism can lead to cancer, contributions to aging and . . .

Roarke Kamber, PhD Portfolio Item

Senescent cells, or cells that have irreversibly stopped dividing and which secrete inflammatory signals, accumulate in both aged tissues and tumors. Senescent cell accumulation is both a hallmark of aging tissues and can promote tumorigenesis in some contexts. It remains unclear why senescent cells persist in many aged tissues and . . .