Han Yang, PhD Portfolio Item
Genetic studies have identified numerous candidate risk loci linked to Alzheimer’s disease (AD), a disease that primarily affects older adults. Nevertheless, the genetic causes of AD are still not fully understood for most late-onset patients. Recent studies suggest that phagocytosis, the process by which microglia engulf and remove toxic substances . . . Theresa Rohm, PhD Portfolio Item
Chronic inflammation, specifically in adipose tissue (fat), drives insulin resistance and type 2 diabetes. Thiazolidinediones (TZDs) are highly effective anti-diabetic drugs that improve how responsive cells are to insulin (insulin sensitivity) and lower blood glucose levels. However, their clinical use is limited by side effects. For decades, scientists have been . . . Ling Fu, MD, PhD Portfolio Item
SType 2 diabetes (T2D) and its associated complications are high-risk factors for mortality and disability. Obesity is a major driving force for T2D. It is important for us to find out why people with obesity are more likely to have diabetes. Glucose production in the liver is increased in obesity, . . . Hiroshi Ebata, PhD Portfolio Item
Aging is a common factor in many diseases, from diabetes to neurodegenerative disorders, and understanding the process of aging is crucial for preventing these illnesses. In our bodies, proteins are the building blocks of cells, each possessing a specific role. However, as we age, some of these proteins become worn . . . Coralie Alexandre, PhD Portfolio Item
Obesity significantly increases the risk of mortality and metabolic comorbidities (type 2 diabetes, atherosclerosis, non-alcoholic fatty liver disease, etc.). This multifactorial disease results from a combination of environmental and genetic factors. Human genetics studies have identified a neural system crucial for the regulation of energy homeostasis, the leptin-melanocortin hypothalamic system. . . . Parminder Singh, PhD Portfolio Item
Aging is a natural process marked by the gradual decline in the functional abilities of living organisms. This process involves various hallmarks, with two critical ones being cellular senescence and insulin resistance, both of which contribute to age-related diseases. Cellular senescence refers to a state where cells lose their ability . . . Karina Cunha e Rocha, PhD Portfolio Item
Obesity significantly increases the risk of metabolic problems, such as insulin resistance and type 2 diabetes. When we gain excess weight, our fat tissue can expand in two ways: hypertrophy, involving the enlargement of existing fat cells, which is associated with inflammation and insulin resistance; and hyperplasia, which generates more . . . 