University of California, San Francisco (UCSF)

Spatiotemporal Patterns of Network Dysfunction in Alzheimer's Disease

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My current research is aimed to investigate spatial and temporal dynamics of network dysfunction in patients with Alzheimer’s disease. I believe that a better understanding of the physiological mechanisms involved, and their functional correlates play a critical role in designing and developing disease-modifying strategies for this devastating disease. I use multimodal imaging approaches combining functional and structural imaging of brain. Magnetoencephalography(MEG), an imaging technique which is capable of neural activity patterns in the brain with very high spatial resolution and precise temporal resolution is one of the novel approaches I utilize in my experiments to study the brain rhythms in healthy individuals and in patients with Alzheimer’s disease. Combining MEG with novel molecular imaging techniques with amyloid and tau tracers I investigate the neurophysiological manifestations of the pathophysiological processes of Alzheimer’s disease.