Abstract

Osteoarthritis (OA) is a prevalent pathological condition characterized by joint degeneration and persistent pain, affecting millions worldwide, especially older adults. Despite its widespread impact, effective treatments remain very limited. My research aims to explore the molecular and cellular changes in bone structural cells and bone-innervating nerves associated with OA, with a particular focus on how aging influences these processes. By studying the interactions between joint structures and sensory neurons in animal models under controlled laboratory conditions, I hope to uncover new mechanisms underlying OA and identify potential therapeutic targets.

I believe that my findings will provide valuable insights into the complex communications between bone joints and the nervous system during aging. This advancement could enhance our understanding of OA and potentially lead to innovative treatment strategies