Abstract

This study aims to understand how different ApoE isoforms interact with LDLR family receptors and how these interactions influence the health and function of human neurons. Although ApoE4 is strongly linked to increased Alzheimer’s disease risk, it remains unclear why its effects differ from those of ApoE2 and ApoE3. We will investigate whether these ApoE forms engage LDLR family receptors differently and how those differences affect cellular balance, protein handling, and communication between neurons. Particular attention will be given to synapses, the connections that allow neurons to exchange signals and support learning and memory. By identifying receptor pathways that contribute to harmful or protective effects, this work may clarify how genetic risk leads to early neuronal dysfunction and reveal new opportunities for preventing or treating Alzheimer’s disease.